Both Nestin+/PHGDH− cells (representing GPC1 subtype) and PHGDH+/Nestin− cells (representing GPC2 subtype) were found in all tumor cores, albeit with different ratios matching their sGPC subtypes (i.e., two sGPC1 tumors contained a higher frequency of Nestin+ cells), whereas two sGPC2 tumors contained higher frequency of PHGDH+ cells (Fig. 5g). Here, PHGDH is linked to neoplasm.