Of the three proteins, PHGDH was the strongest biomarker (univariate Cox P = 0.0071) associated with long-term survivors of IDH wild-type GBM patients in the SMC1 cohort (Fig. 4c), as well as in other independent data sets at the mRNA-level (Supplementary Fig. 4b). This evidence concerns the gene IDH1 and glioblastoma.