Of the core Ot genes, among those most differentially expressed between Karp and UT176 were scaE, tsa56, and tsa22 (1.40, 3.08, and 3.96 logFC in Karp over UT176, respectively), and differential expression was confirmed by qRT-PCR in an independent infection experiment (Supplementary Fig. 12A). The gene discussed is POLG; the disease is infection.