IKZF1 and systemic lupus erythematosus: These results confirm that SLE-associated OCR located hundreds to thousands of kilobases away in 1D interact with and act as crucial regulatory elements for the genes encoding the master TFH transcription factor BCL6, the IKZF1 transcriptional repressor, and the TFH chemokine receptor CXCR5. These results indicate that the 3D promoter connectomes detected in these cells reveal bona fide gene regulatory architectures.