An example is rs112677036, a proxy to the SLE sentinel SNP rs12938617 that resides in the first intron of IKZF3, interacts with nearby IKZF3 promoter, but also interacts with promoters of two 157 kb upstream genes PGAP3 and ERBB2 (Fig. 6b, Supplementary Fig. 3g, h). Here, ERBB2 is linked to systemic lupus erythematosus.