MAPT and Alzheimer disease: Studies in this area have shown conflicting results with (i) no difference between AD and control patients47,49,50, (ii) differences in plasma Aβ1–4245,58, Tau57 and p-Tau54 concentrations between AD and control patients, and (iii) differences in plasma Aβ1–4253,58, Tau, and p-Tau54 levels among patients with MCI due to AD, patients with AD, and control subjects.