In the largest PDAC CTC subgroup, we noted robust expression of LIN28B, an oncofetal RNA-binding protein that exerts diverse effects primarily via negative regulation of let-7 microRNA (miRNA) maturation16 and whose expression correlates with poor outcome in many tumor types including PDAC17; our data also show a negative impact of LIN28B PDAC CTC expression and overall survival. The gene discussed is LIN28B; the disease is neoplasm.