Treatment of pancreatic cancer cells with a selective inhibitor of LIN28B/let-7 binding (LIN28 inhibitor: N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide) that has been previously shown to facilitate differentiation of embryonic stem cells via let-7 de-repression34 also de-repressed mature let-7 expression (qPCR) in PDAC cells (Supplementary Fig. 11c). The gene discussed is LIN28B; the disease is familial pancreatic carcinoma.