On the other hand, TGF-β is a known metastatic driver48 and in pancreatic cancer can increase expression of both LIN28B and MIR-100HG – a lncRNA that is then processed into multiple miRNAs (mir-100, miR-125b-1, let-7a-2)27. This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.