miR-145-5p is involved in HCC-associated signaling pathways, such as Wnt, TGFβ and Ras, interacts with circular RNA in HCC (Qiu et al., 2019) and is one of the integrated signature of 13 microRNAs identified in HCC (Shi et al., 2015). This evidence concerns the gene TGFB1 and hepatocellular carcinoma.