CD274 and neoplasm: Consistent with the above observations, 4 T1 cells with B3GNT3 knockout grew slower in immunocompetent BALB/c mice than did 4 T1 knockout control cells, but not in immunodeficiency SCID mice, suggesting that reduced tumor growth in the absence of B3GNT3 is partially attributed to the changes in PD-L1 glycosylation and subsequent PD-L1/PD-1 interaction [36].