Researchers further showed that EGF/EGFR signaling induces PD-L1 glycosylation and stabilization via GSK3β inactivation whereas pharmacologically antagonizing this process destabilizes PD-L1 and enhances the efficacy of PD-1 blockade in syngeneic mouse models of TNBC and colon cancers [23]. This evidence concerns the gene CD274 and malignant colon neoplasm.