CD274 and Familial prostate cancer: In TNBC and prostate cancer cells, Sigma1, an ER receptor chaperone, physically associates with glycosylated PD-L1; treatment with Sigma1 inhibitor, 1-(4-iodophenyl)-3-(2-adamantyl) guanidine (IPAG), induces PD-L1 degradation via autophagy, which reduces PD-L1 expression and activates co-cultured T cells [45] (Fig. 2).