CD274 and neoplasm: Consistent with the results by immunofluorescence and ELISA, PD-L1 detection by IHC was significantly enhanced in samples from human tumor tissue microarrays of various cancer types after sample deglycosylation; among them, a majority of patient samples (37.5–57.5%) increased PD-L1 IHC detection by more than 2-fold [86].