HLA-G and nonpapillary renal cell carcinoma: In the search of complementary angiogenic strategies to improve the clinical response of ccRCC patients, we have asked whether combining conventional anti-angiogenic therapies with blockade of the immune checkpoint HLA-G/ILT4 might be associated with a significant improvement in durable response rate since previous studies suggested an intricate interplay between angiogenesis and immune-surveillance [38].