HLA-G and neoplasm: Even though the different regulatory cascades which simultaneously involve either VEGF-A or VEGF-C are still to be clearly determined, we propose considering the establishment of protocols associating the anti-VEGF-A antibody Bevacizumab, which should prevent the increase in the levels of VEGF-A, with the blockade of HLA-G, which should prevent tumor progression and metastases by decreasing the levels of VEGF-C and re-activate the immune system.