IFNG and Intervertebral disk degeneration: To our knowledge, the current study was one of the firsts to investigate the association of cytokine polymorphisms including IL-2 (− 330 T/G, + 166G/T), IL-12 (−1188A/C) and IFN-γ (=874A/T) with intervertebral disc degeneration (IVDD) in Iranian patients.