Ellagic acid exerted a renoprotective effect by suppressing the NOX4/JAK/STAT signaling pathway (ellagic acid suppressed the phosphorylation of JAK1, JAK2, and STAT1 and reduced the level of NOX4) and reduced apoptosis, hypoxia-induced inflammatory response, and ROS levels, resulting in reduced acute kidney injury in the clinic [18]. This evidence concerns the gene JAK2 and acute kidney injury.