In addition to Th17 cells and Treg cells, many immunoregulatory cells, such as Th2 cells, Th1 cells, innate lymphoid cells, dendritic cells, natural killer T cells, and TH9 cells, and many endogenous cytokines related to asthma, such as IL4, IL-5, IL13, IL22, and IL25, are also involved [1]. The gene discussed is IL25; the disease is asthma.