One and 5 μg/ml BioPM collected from chicken, goat and pig farms induced the production of IFNγ, IL-10, IL-1β and TNFα by PBMCs from stable asthma patients and healthy volunteers in an apparent concentration-dependent manner (except for TNFα production induced by BioPM from the goat farm) (Fig. 1). The gene discussed is IL1B; the disease is asthma.