Eleven hub genes, namely SMOC2, NRK, PDE5A, CTSK, MXRA5, CRISPLD1, COL14A1, SFRP4, OGN, PI16, HTRA1 and C1QTNF2 are likely to be prognostic biomarkers for development of HF. This evidence concerns the gene HTRA1 and hydrops fetalis.