Eleven hub genes, namely SMOC2, NRK, PDE5A, CTSK, MXRA5, CRISPLD1, COL14A1, SFRP4, OGN, PI16, HTRA1 and C1QTNF2 are likely to be prognostic biomarkers for development of HF. Here, SFRP4 is linked to hydrops fetalis.