After identifying the hub genes in the blue module underlying the studied traits (HF, ISCH and CMP), we identified 12 hub genes as those common to the three studied traits including SMOC2, NRK, PDE5A, CTSK, MXRA5, CRISPLD1, COL14A1, SFRP4, OGN, PI16, HTRA1 and C1QTNF2. This evidence concerns the gene SFRP4 and hydrops fetalis.