These results in 3xTg-AD mice correlate well with imaging and postmortem studies in human AD demonstrating widespread abnormalities in oligodendrocytes and myelin, including reduced MBP (Bartzokis, 2011; De Rossi et al., 2016; Ihara et al., 2010; McKenzie et al., 2017; Nasrabady et al., 2018; Roher et al., 2002). This evidence concerns the gene MBP and Alzheimer disease.