The triple transgenic mouse model of AD (3xTg-AD) harbors presenilin 1 (PS1; M146 V), amyloid precursor protein (APP; Swe), and tau (P301 L) transgenes, and displays progressive AD-like pathology and cognitive impairments in an age-related manner (Belfiore et al., 2019; Oddo et al., 2003; Olabarria et al., 2010). The gene discussed is PSEN1; the disease is Alzheimer disease.