CSPG4 and Alzheimer disease: To examine whether this occurs in 3xTg-AD, we performed a detailed morphological analysis of NG2 immunostained OPCs in the hippocampus at 6 and 24 months (Fig. 3), using the Cell Analyst program and morphological parameters detailed by (Chvátal et al. 2007), as described previously for astrocytes in the 3xTg-AD model (Rodríguez et al., 2013).