Indeed, white matter changes are an early feature of human AD (Fischer et al., 2015; Hoy et al., 2017), and the premature loss of MBP immunostaining observed in our study is consistent with myelin loss being an early event in AD pathology and cognitive decline (Butt et al., 2019; Nasrabady et al., 2018; Wang et al., 2020). Here, MBP is linked to Alzheimer disease.