WNT10A and Schöpf-Schulz-Passarge syndrome: The data indicate that mutations in seven of these genes (PAX9, WNT10A, MSX1, WNT10B, LRP6, AXIN2, EDA) are responsible for 91.9% of these cases.2,5,6,8,10,12,15,18,19 Authors suggested that mutated genes encoding the components in the canonical Wnt/β-catenin pathway and Wnt-associated genes have higher genetic risk for isolated TA compared to genes which play roles in other pathways.2,5,8,10,15,18,19WNT10A variants are associated with both selective TA 4 (STHAG4), odontoonychoectodermal dysplasia (OODD) and Schopf–Schulz–Passarge syndrome (SSPS).4