Thioredoxin system is composed of the anti‐oxidant thioredoxin‐1 (TXN1), thioredoxin reductase (TXNRD1), thioredoxin peroxidase‐1 (PRDX1), and the pro‐oxidant thioredoxin‐interacting protein (TXINP), which functions as a crucial defense mechanism against oxidative damage in cardiovascular diseases.43, 44. This evidence concerns the gene PRDX5 and cardiovascular disorder.