Results of Table 1 elaborated that MEG3 methylation was associated with low MEG3 expression, large tumor size (≥2 cm), advanced TNM grade, and high histological grade (ie, G3) (all P < .05), rather than age, ER status, PR status, HER2 status, and lymphatic metastasis (P > .05), of BC patients. This evidence concerns the gene ESR1 and breast cancer.