Here, over‐expressed MEG3 (ie, pcDNA‐MEG3 transfection) and de‐methylated MEG3 (ie, 5‐Aza‐dC treatment) were found to elevate the apoptotic rate of MDA‐MB‐231 and MCF‐7 cell lines (Figure 3C,D), which suggested that enhancive BC apoptosis might be another mechanism explaining MEG3’ reinforcing BC chemosensitivity. This evidence concerns the gene MEG3 and breast cancer.