However, it has been described that IL‐18 secretion was reduced in both unstimulated and LPS‐stimulated monocytes from patients with atopic dermatitis.[46] This is an interesting subject for a follow‐up study as it will indeed determine whether our observations are specific for HS patients or more general for fibrosis and other inflammatory skin diseases, for example Rosacea, keratosis pilaris, eczema and psoriasis. The gene discussed is IL18; the disease is histiocytic sarcoma.