AOX has also been expressed in two mouse models of mitochondrial disease, with apparently beneficial effects in Bcs1lp.S78G knock‐in mice but exacerbation of mitochondrial myopathy secondary to aberrant redox signalling in the skeletal muscle‐specific Cox15 knockout mouse crossed with an AOX‐transgenic mouse.47, 88. The gene discussed is ACOX1; the disease is mitochondrial disease.