However, with the use of genome‐wide association studies and next‐generation sequencing have delineated several gene mutations in CVID including CD19, CD20, CD21, CD81, TACI (TNFRSF13B), BAFF (TNFRSF13C), PTEN, PI3KD, PIK3R1, TWEAK, TRNT1, TTC37, NFKB1, NFKB2, IKZF1, IRF2BP, ATP6AP1, ITPKB, PRKCD, LRBA, and ICOS.13, 32, 33. This evidence concerns the gene PIK3R1 and common variable immunodeficiency.