Overexpressed negative immune regulatory molecules of M2‐like TAMs, such as Arg‐1, IL‐10, programmed cell death 1 ligand (PD‐L1) and cytotoxic T lymphocyte antigen 4 (CTLA‐4), inhibited the effect of CD4+ and CD8+ T cells to induce immunosuppressive microenvironment for tumour development.16, 17, 18, 19, 20. This evidence concerns the gene CD274 and neoplasm.