With respect to the best timing for performing PSMA PET/CT, some evident prerequisites were confirmed, such as that in case of primary PCa negative on PSMA PET/CT, further imaging with PSMA PET/CT is generally not adequate (statement 2.1), and if used for response assessment, baseline PSMA PET/CT should be performed before the start of treatment (statement 2.2). Here, FOLH1 is linked to posterior cortical atrophy.