In support of this, a nitric oxide delivery system has been shown to increase vascular permeability in tumor tissue, resulting in a selective increase in the delivery, and enhanced effectiveness, of nanoparticle albumin‐bound paclitaxel (Abraxane®) in pre‐clinical models of solid cancer with inherently high or low leakiness.64, 65. The gene discussed is ALB; the disease is neoplasm.