CDH2 and neoplasm: While the mechanism(s) of synergy are unclear, N‐cadherin has been shown to increase pro‐survival signaling in cancer cells, including activation of Bcl‐273, 74, 75 and NF‐кB76 pathways, known to play key roles in MM tumor cell survival and resistance to anti‐MM agents.77, 78, 79, 80, 81, 82