Eleven studies with 51 patients were included in the meta-analysis (all observational cohorts). Patient age ranged from 4th to 10th decade of life (average: 9.3 decade), and 40.1% received IV tissue plasminogen activator (tPA). Initial National Institutes of Health Stroke Scale (NIHSS) score ranged from 1 to 36 (average 17.6). Of the 51 patients, 39 (76%) patients suffered from anterior circulation LVOs versus 12 (24%) from posterior circulation. This evidence concerns the gene PLAT and Stroke.