Consistent with the previous studies, this study also confirmed the frequent mutation of TP53, ZNF750, FAT1, PTCH1, EP300, FAT2, FBXW7, KMT2D, NFE2L2, NOTCH1, PIK3CA, RB1, RIPK4 and TP63 in ESCC patients (Chang et al., 2017; Sawada et al., 2016; Qin et al., 2016). This evidence concerns the gene TP53 and esophageal squamous cell carcinoma.