The AAA formation was reduced by 80% by simvastatin in Nrf2 tKO mice (Figures 1(a) and 1(b)), and sudden death caused by the aneurysm rupture was also abolished (3/14 vs. 0/11 in AngII vs. Sim+AngII groups; Figure 1(c)). The gene discussed is NFE2L2; the disease is aneurysm.