APOE and hyperlipidemia: However, given the debatable role of hyperlipidaemia in aneurysm etiology [17, 18] and possible aggravation of aneurysm formation under Nrf2 transcriptional deficiency, we decided to use a model of AngII-induced AAA combined with fat-enriched diet in C57BL6/J mice, instead of the ApoE KO mice.