To examine the effect of TREM2 overexpressed on inflammatory response, mRNA levels of proinflammatory mediators (IL-1β, IL-6, and TNF-α), anti-inflammatory mediators (IL-4, IL-10, and TGFβ), and chemokine cytokines (MIP-1α, MCP-1) were measured by RT-PCR in VD mice. The gene discussed is IL4; the disease is sexually transmitted disease.