Compared to LPS-activated non-CF MDMs, we found that in vitro modulator-pretreatment in LPS-activated CF MDMs from patients on prescribed modulators had elevated lactoferrin secretion (P = 0.0618, Supplementary Fig. S3f), and significantly lower transferrin (P = 0.0076, Supplementary Fig. S3g). Here, TF is linked to cystic fibrosis.