CASP1 and cystic fibrosis: Findings in the literature suggest that differences in CF inflammasome activity may be observed in a context-dependent manner: CF airway epithelial cells and CF monocytes have similar IL-1β and caspase-1 activity in response to LPS71, while CF MDMs challenged with Burkholderia cenocepecia secrete significantly more IL-1β than non-CF50, and CFTR knockout mice challenged intranasally with Aspergillus fumigatus conidia or Pa express elevated IL-1β in lung homogenates72.