CD274 and cancer: The top canonical pathways predicted for the WM8 module among all the clinical traits were the antigen presentation pathway (p = 2.00 × 10−17), allograft rejection signalling pathway (p = 2.51 × 10−12), OX40 signalling pathway (p = 3.16 × 10−12; z-score =  − 2), PD-1/PD-L1 cancer immunotherapy pathway (p = 1.26 × 10−11; z-score =  − 2) and T helper 1 pathway (p = 3.16 × 10−11; z-score = 2).