The WM23, WM53 and WM8 modules appeared to be involved in various pathways related to cancer cell survival and death, such as the Golgi to ER retrograde traffic system; NRAGE signalling death through JNK and cell death signalling via NRAGE, NRIF and NADE; and immune pathways including PD-1 signalling, MHC class II antigen presentation and interferon-gamma signalling. The gene discussed is BEX3; the disease is cancer.