No significant changes were observed for most of the common lymphatic markers, namely PDPN, PROX-1, LYVE-1, CCL21 but a 1.9-fold (P = 0.02) increase was observed in the expression of VEGFR-3 in lipedema in comparison to the control (Fig. 4a). The gene discussed is PROX1; the disease is Lipedema.