VEGFD and Lipedema: Interestingly, increased levels of VEGF-C were observed in lipedema patients in comparison to the control patients (C: 3,275 ± 678 pg/ml, L: 4,364 ± 1,204 pg/ml, P = 0.02, 1.33-fold increase) (Fig. 1b), without any significant differences in the levels of VEGF-A (C: 220 ± 158 pg/ml L: 281 ± 112 pg/ml) and VEGF-D (C: 387 ± 101 pg/ml L: 400 ± 104 pg/ml) (Fig. 1a,c).