Moreover, it was noticed that the immune response of tumour IM was higher in PD-1+CD8+ TIL ACT group than in the control group: B2m, a component of MHC-I molecules, was elevated in the margin of tumour nest, and there were more PD-L1+ TILs (Fig. 6e, f). The gene discussed is B2M; the disease is neoplasm.