CD8A and neoplasm: Among primary-to-recurrent lesion transitions, 15 (68.2%) were pattern changes; among 6 tumour changes, 5 (83.3%) were “Pushing” to “Infiltrating” transition; among 11 CD8+ TIL pattern changes, all were “inflamed” to “deserted” transition (Supplementary Fig. S4d–f; Fig. 1g).