We previously demonstrated that MCAs generated from epithelial- and mesenchymal-type ovarian cancer cells possess dramatically different phenotypes, ranging from loosely adhesive clusters (formed by purely epithelial-type E-cadherin expressing EOC cells) to highly cohesive solid spheroids (formed by purely mesenchymal-type N-cadherin-expressing EOC cells)24. The gene discussed is CDH2; the disease is ovarian cancer.