Tumor driver mutations found in pediatric glioblastoma (GBM) include BRAFV600E point mutations, alterations in NF1, TP53, EGFR, and PDGFRA with or without concurrent CDKN2A/B deletions, and histone 3.3 G34R/V mutations5–10. The gene discussed is PDGFRA; the disease is glioblastoma.