Pathways related to these cells included: Fcγ receptor-mediated phagocytosis; TREM1 signaling, which plays important roles in innate immune responses, such as activating inflammatory responses20; dendritic cell maturation; hepatic fibrosis associated with an accumulation of extracellular matrix (ECM) proteins21; the pathway related to B cell receptor signaling; and multiple cell populations associated with OA including I-MΦ, DC and iFIB (Fig. 2b). The gene discussed is TREM1; the disease is Hepatic fibrosis.