MS is considered a multifactorial disease with environmental and genetic components, whereby genetic and dietary animal models exist; in general, genetic models are related to the mutation of the leptin receptor which induces hyperphagia, which leads to an energy imbalance that favors obesity, IR, dyslipidemias, glucose intolerance and eventually T2DM, these models are closely related to the genetic components of MS and have been reviewed elsewhere5,6. This evidence concerns the gene LEPR and myeloid sarcoma.