Subsequently, Yi et al. 16, studied three WMS siblings with brachydactyly and identified a nonsense variant (p.Lys351*) in ADAMTS17. Finally, Karoulias et al. 12, reported a pathogenic ADAMTS17 missense variant (p.Thr343Ala) in a singleton WMS patient with no evidence of brachydactyly. The gene discussed is ADAMTS17; the disease is Weill-Marchesani syndrome.