In addition, p53 can induce apoptosis when irreparable damage occurs.205,206 Accumulating evidence indicates a lack of crucial tumor suppressors (including, but not limited, to RB and p53) stimulating progression to neoplasia.201,207,208 More and more non-oncology drugs are being repurposed to target cancer cells evading growth suppressors. The gene discussed is RB1; the disease is neoplasm.