IL2 and neoplasm: Culturing peripheral blood mononuclear cells (PMBCs) or tumor explants in the presence of exogenous IL-2 results in the survival and selective enrichment of T cells, so we referred to them in a general term as “tumor-infiltrating immune cells.” A total of 750 upregulated and 1073 downregulated transcripts were identified in TIICs treated with pembrolizumab, compared with the non-treated TIICs.