Genes encoding for integrins (such as ITGAV, ITGBL1, and ITGB1) that can promote tumor cell proliferation and migration [34] and genes related to the Hippo signaling pathway, one of the signaling pathways which has been implicated in cancer by promoting cell proliferation [35], were also downregulated (Figure 3E). The gene discussed is ITGB1; the disease is cancer.