Collectively, these data showed that anti-TIM-3 mAb can enhance anti-tumor immunity by upregulating genes that favor immune cell proliferation/activation and T cell cytotoxicity, and it can also suppress tumor angiogenesis, growth, invasion, and metastasis by downregulating genes associated with the JAK–STAT and Wnt signaling pathways, and integrins [34,36,37]. Here, HAVCR2 is linked to neoplasm.