Some of these genes, which interfere with tumor cell growth/differentiation/migration/invasion (such as MYC, MET, PROM1, and PTK2), induce hypoxia (such as ARNT2, HIF3A, TGB2, MMP2, and POSTN) and genes regulating transcription via acetylation were downregulated upon pembrolizumab treatment (Figure 2F). Here, HIF3A is linked to neoplasm.