Similar to pancreas-specific loss of BMAL1, we observed significant hyperglycemia without a concomitant increase in insulin (Supplemental Fig. S3B,C), and PdxCre;Clockflx/flx mice were glucose intolerant and displayed reduced insulin secretion following a glucose challenge compared with their littermate controls (Supplemental Fig. S3D). This evidence concerns the gene BMAL1 and Hyperglycemia.