HP and diabetes mellitus: The positive association of α2,6-sialylation of diantennary glycans (A2E) with metformin and statin is in line with earlier findings associated with diabetes.19 The majority of α2,6-sialylated diantennary glycans are present on acute-phase proteins, haptoglobin and IgM, and a shift in α2,6-sialylation might potentially affect their ability to bind siglec-2.29 30 Siglec-2 is a lectin with an important immunological function, recognizing α2,6-sialylated glycans expressed on B cells, and functioning as a molecular switch to apoptosis or activation of B cells.31