A decrease of A2F has previously been associated with type 2 diabetes itself,19 acute inflammation36 and increased C reactive protein (CRP).37 The majority of fucosylated diantennary glycans in plasma are thought to be derived from Igs.34 The total abundance of fucosylated, non-sialylated diantennary species (TA2FS0) was decreased and the bisection of these glycans (A2FS0B) was increased in metformin and statin users. Here, CUBN is linked to type 2 diabetes mellitus.