AFP and hepatocellular carcinoma: Based on the ANN-model, this panel had a sensitivity of 73.4% and a specificity of 90.1% for HCC detection (HCC vs. controls [healthy + cirrhotic], AUC = 0.902) (Table 1), as well as a sensitivity of 80.6% and a specificity of 90.1% for AFP− HCC detection (AFP− HCC vs. Controls [healthy + cirrhotic], AUC = 0.926) (Table 2).