In the subcortical white matter, CD68 expression was significantly higher in sporadic ALS-TDP cases than SOD1 (p = < 0.0001) and FUS cases (p = 0.0006), and also significantly higher in C9ORF72 cases than SOD1 cases (p = 0.0001) (Fig. 2i). Here, FUS is linked to amyotrophic lateral sclerosis.