Using GAD67-pTDP-43 double labelling in seven ALS cases assessed (see supplementary material for individual cases), we found that GAD67 neurons were devoid of granular or compact pTDP-43 aggregates, even in areas that otherwise contained typical ALS-TDP neuropathology (Fig. 5e-g). The gene discussed is GAD1; the disease is amyotrophic lateral sclerosis.