Many ALS-FUS and ALS-SOD1 cases exhibited cortical CD68 comparable to that of controls but showed significant staining within the spinal cord anterior horn (Fig. 4t,u), and 80% of all non-TDP-43 proteinopathies assessed fell below the calculated median predominance ratio of our cohort (Fig. 4m; Supp Figure 5). Here, SOD1 is linked to amyotrophic lateral sclerosis.