pTDP-43 aggregation was amongst the lowest in the single TARDBP mutation case assessed (Fig. 2a,g; supp Figure 2), however notably it has not been formally established that the pattern and/or severity of pTDP-43 pathology in TARDBP mutation cases is the same as in ALS-TDP or C9-ALS. Here, C9 is linked to amyotrophic lateral sclerosis.