We found a strong positive correlation between the extent of p62 and pTDP-43 in sporadic ALS [Pearson r(16) = 0.61, p = 0.006](Fig. 2j), however this relationship was not observed in C9-ALS to the same degree [Pearson r(14) = 0.53, p = 0.03](Fig. 2j), reflecting the existence of p62-positive, pTDP-43-negative dipeptide repeat proteins produced as a consequence of the C9ORF72 expansion. This evidence concerns the gene C9 and amyotrophic lateral sclerosis.