TARDBP and amyotrophic lateral sclerosis: It allows us to contribute several important findings to the field: First, in the group of ALS associated with phosphorylated (p)TDP-43 proteinopathy, sporadic disease was characterised by a higher pTDP burden in the motor cortex than C9-ALS, and all genotypes in this group demonstrated oligodendroglial pTDP-43 inclusion body pathology.