PRDM8 and cancer: Therefore, FGF5, ANTXR2, and C4orf22 may play a key role in regulating hypoxia stress, while PRDM8 is a novel gene associated with hypoxic adaptation, the expression of which may be mirrored by decreased expression of SOX6 and HIF1α. FGF5 was originally reported as a key human oncogene [66], associated with a number of cancers [67], angiogenesis in human aortic endothelial cells [68], and trichomegaly in humans [69].