For example, the deleterious mutations in the PTCHD1 (patched domain containing 1) gene have been described in male patients with X-linked autism spectrum disorder (ASD) and/or intellectual disability (ID) [29, 30], which further been found that the deficiency of PTCHD1 could also induce excitatory synaptic and cognitive dysfunctions in mouse [31]. The gene discussed is PTCHD1; the disease is Intellectual disability.