CD19 and diffuse large B-cell lymphoma: The administration of tisagenlecleucel (the first CAR-T drug used in the world) to adult patients with R/R diffuse large B cell lymphoma resulted in an overall response rate of 52%, with 40% of the patients achieving a complete response; the overall response rate of anti-CD19 CAR-T cells in clinical trials was greater than 80% for patients with B cell acute lymphoblastic leukemia (ALL) and non-Hodgkin’s lymphoma (NHL) [5].