Resuscitation promoting factor B and D induced a significantly higher IFN-γ response in infected compared to TB diseased children (medium (IQR) 47.1 (7.1–129.8) pg/mL versus 9.1 (0.0–75.3) pg/mL, P = 0.02 and 91.1 (40.9–284.5) pg/mL versus 60.1 (11.0–114.2) pg/mL, P = 0.03) respectively (Fig. 2). Here, IFNG is linked to tuberculosis.