The transcription of these two genes might be regulated by the same promoter region as SH3TC2 was also shown to be up-regulated in gastric cancer (P = 1.7e-8) (Fig. 1d), which significantly and strongly correlated with miR-584 in gastric (P = 1.79e-75, r = 0.774) (Fig. 1e) and other panels of human cancers (Supplementary Figure 2). The gene discussed is SH3TC2; the disease is gastric cancer.