LDHA and cancer: The second combination present in all three cell lines is DCA (PDH activation [55]) + NHI-2 (LDH-A inhibition [56]) which showed a “strong” synergism for the cancer cell line MCF-7 (CI = 0.27) and “robust” synergisms for HT-29 (CI = 0.50) and MDA-MB-231 (CI = 0.62).