PODXL and cancer: On the other hand, among these eligible 18 papers, 5 studies involved the expression locations of PODXL and the prognosis of cancers, and only 2 studies, including 4 cohorts, showed the association between membrane expressed PODXL and poor OS (HR = 2.98, 95% CI =1.29–6.90, P = 0.011), also by using the random-effect model (I2 = 84.7%, P < 0.0001) (Fig.2d).