Subgroup analysis showed that, high expressed PODXL were linked with poor OS in colorectal cancer (HR = 1.79, 95% CI = 1.35–2.37, P < 0.0001), pancreatic cancer (HR = 2.98, 95% CI = 1.95–4.55, P < 0.0001), urothelial bladder cancer (HR = 2.14, 95% CI = 1.48–3.10) and other cancers (HR = 2.60, 95% CI = 1.45–4.66, P = 0.001), but not in patients with the gastric cancer (HR = 2.76, 95% CI = 0.45–15.84, P = 0.256). The gene discussed is PODXL; the disease is cancer.