Low levels of neprilysin have been reported to be associated with cardiovasciular risk factors such as hypertension and smoking as well as diastolic left ventricular dysfunction in a large community-based cohort of 1536 participants without known cardiovascular disease (median of 3.9 ng/mL [IQR: 1.0, 43.0 ng/mL] [15]). This evidence concerns the gene MME and cardiovascular disorder.