The data showed that the expression levels of the autophagy-related gene set in the primary tumors derived from ER(-) breast cancer patients who are positive for lung metastasis and in the group with high levels of Gαh on the basis of the Kaplan-Meier analysis [16] were much lower than those of ER(-) breast cancer patients without lung metastasis and in the group with low levels of Gαh (Figure 6A). The gene discussed is ESR1; the disease is breast cancer.