Whereas the mRNA levels of the mTORC1 gene set and Gαh appeared to be negatively correlated in the non-lung metastatic ER(-) breast cancer tissues, their expression levels were significantly and positively correlated in the lung metastatic ER(-) breast cancer tissues with high Gαh levels (p<0.0001) (Figure 1D). This evidence concerns the gene ESR1 and breast cancer.